SCHEMBL8944060

SCHEMBL8944060

COc1ccc(Nc2cccc(Oc3ccc(Oc4ccc(Oc5ccccc5N(c5ccccc5)c5ccccc5)cc4)cc3)c2Nc2ccc(OC)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.44
MAPK1 P28482 3/20 0.44
ALOX12 P18054 1/20 0.44
HSD17B10 Q99714 1/20 0.44
RAB9A P51151 4/20 0.43
ALDH1A1 P00352 5/20 0.41
KMT2A Q03164 4/20 0.41
MEN1 O00255 3/20 0.41
GAA P10253 3/20 0.41
HTT P42858 2/20 0.41
KDM4E B2RXH2 2/20 0.41
THRB P10828 2/20 0.41
RECQL P46063 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
MMP14 P50281 1/20 0.41
KDM1A O60341 1/20 0.40
POLB P06746 1/20 0.40
RAD52 P43351 1/20 0.40
GFER P55789 1/20 0.40
RAF1 P04049 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8944011 0.92 MAPT (0.39) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8944040 0.85 ALDH1A1 (0.54) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8943622 0.84 ALDH1A1 (0.56) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8943619 0.80 ALDH1A1 (0.51) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8943962 0.78 ALDH1A1 (0.51) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8943996 0.76 ALDH1A1 (0.47) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8944203 0.75 GAA (0.44) MAPTRAB9AALDH1A1GAAKDM4E
SCHEMBL8944031 0.74 MAPT (0.45) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8943655 0.73 MAPT (0.45) MAPTMAPK1ALOX12HSD17B10RAB9A
SCHEMBL8943982 0.73 ALDH1A1 (0.43) MAPTMAPK1ALOX12HSD17B10RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5480765-A PRESSURE AND HEAT SENSITIVE PAPER, IMPROVED PHOTOSTABILITY BY ADDITION OF TRIARYLAMINE COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1996-01-02 US disclosed