SCHEMBL8944701

SCHEMBL8944701

CC(C)CCC1OC1C(Cc1ccccc1)NC(=O)[C@@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSD P07339 3/20 0.76
CYP3A4 P08684 3/20 0.47
ABCC3 O15438 1/20 0.47
ABCC4 O15439 1/20 0.47
CACNA1F O60840 1/20 0.47
ABCB11 O95342 1/20 0.47
ABCB1 P08183 1/20 0.47
HTR1A P08908 1/20 0.47
DRD2 P14416 1/20 0.47
TACR2 P21452 1/20 0.47
TBXAS1 P24557 1/20 0.47
OPRM1 P35372 1/20 0.47
DRD3 P35462 1/20 0.47
AVPR1A P37288 1/20 0.47
OPRD1 P41143 1/20 0.47
OPRK1 P41145 1/20 0.47
HTR2B P41595 1/20 0.47
CACNA1D Q01668 1/20 0.47
SLC6A3 Q01959 1/20 0.47
KCNH2 Q12809 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8800871 0.85 CTSD (0.86) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL8801420 0.84 CTSD (0.78) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL8801929 0.83 CTSD (0.82) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL7313674 0.83 CTSD (0.80) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL8801156 0.83 CTSD (0.77) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL8801937 0.82 CTSD (0.78) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL8801592 0.82 CTSD (0.77) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL8802750 0.81 CTSD (0.76) CTSDCYP3A4ABCC3ABCC4CACNA1F
SCHEMBL8664078 0.80 CTSD (0.60) CTSDCCR1PSMB5
SCHEMBL8664364 0.80 CTSD (0.49) CTSDCTSKCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5587388-A AIDS; VIRICIDES LUCKY LIMITED (KR) 1996-12-24 US disclosed