Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1942173 | 0.77 | MAPT (0.39) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL5548236 | 0.74 | CACNA1A (0.41) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL12881673 | 0.72 | MAPT (0.37) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL5307104 | 0.72 | ALDH1A1 (0.39) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL69308 | 0.70 | MAPT (0.44) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL1023246 | 0.70 | MAPT (0.44) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL1206077 | 0.69 | POLB (0.36) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL3316195 | 0.69 | POLB (0.36) | MAPTFKBP1AALDH1A1KMT2AMEN1 | |
| SCHEMBL16854915 | 0.69 | CACNA1A (0.43) | MAPTFKBP1AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL11147800 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |