Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.66 |
| ▸ | HTR2B | P41595 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945056 | 0.87 | MAPT (0.67) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL7660018 | 0.79 | HTR2C (1.00) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL6589222 | 0.79 | HTR2C (0.74) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL8944943 | 0.78 | HTR2B (0.75) | HTR2CHTR2BMAPTMEN1TP53 | |
| Hydrochloric Acid SCHEMBL8945116 | 0.78 | HTR2C (0.72) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL173735 | 0.78 | MAPT (1.00) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL29391435 | 0.78 | MAPT (1.00) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL8944979 | 0.78 | HTR2B (0.74) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL29729330 | 0.78 | MAPT (1.00) | HTR2CHTR2BMAPTMEN1TP53 | |
| SCHEMBL7660978 | 0.78 | HTR2C (0.69) | HTR2CHTR2BMAPTMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508288-A | Indole derivatives as 5HT1C antagonists | SMITHKLINE BEECHAM, P.L.C. (GB) | 1996-04-16 | — | — | US | disclosed |