SCHEMBL8945707

SCHEMBL8945707

COc1ccccc1CCCCc1c(O)c2cc(-c3ccccc3)ccc2oc1=O

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 4/20 0.46
CNR2 P34972 4/20 0.45
TP53 P04637 1/20 0.44
MAPT P10636 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
POLB P06746 1/20 0.44
CNR1 P21554 1/20 0.42
GPR55 Q9Y2T6 1/20 0.42
MAOB P27338 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8945586 0.88 NQO1 (0.58) NQO1CNR2TP53MAPTRXFP1
SCHEMBL8945339 0.86 NQO1 (0.47) NQO1CNR2TP53MAPTRXFP1
SCHEMBL8945436 0.86 VKORC1 (0.55) NQO1CNR2TP53
SCHEMBL7379480 0.83 VKORC1 (0.55) NQO1CNR2TP53
SCHEMBL6952277 0.82 NQO1 (0.54) NQO1CNR2TP53POLB
SCHEMBL8945678 0.81 NQO1 (0.63) NQO1CNR2TP53MAPTPOLB
SCHEMBL8945643 0.79 MAPT (0.44) NQO1CNR2MAPTPOLBCNR1
SCHEMBL8945542 0.76 CNR2 (0.52) NQO1CNR2MAPTPOLBCNR1
SCHEMBL7356922 0.73 NQO1 (0.52) NQO1TP53
SCHEMBL8808578 0.73 NQO1 (0.67) NQO1MAPTGPR55MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5510375-A VIRICIDES TREATING INFECTION CAUSED BY HUMAN IMMUNODEFICIENCY VIRUS AND AIDS WARNER-LAMBERT COMPANY (US) 1996-04-23 US disclosed