Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 3/20 | 0.30 |
| ▸ | MAOB | P27338 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nerispirdine SCHEMBL29379158 | 0.90 | SLC6A2 (0.67) | BCHESLC6A2CYP2D6 | |
| Nerispirdine SCHEMBL3842518 | 0.90 | SLC6A2 (0.67) | BCHESLC6A2CYP2D6 | |
| Nerispirdine SCHEMBL3855895 | 0.89 | SLC6A2 (0.65) | BCHESLC6A2CYP2D6 | |
| SCHEMBL7614150 | 0.84 | SLC6A2 (0.50) | BCHESLC6A2CYP2D6ACHEMAOA | |
| Hydrochloric Acid SCHEMBL7609627 | 0.83 | SLC6A2 (0.49) | BCHESLC6A2CYP2D6 | |
| SCHEMBL7611577 | 0.83 | SLC6A2 (0.49) | BCHESLC6A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL7613979 | 0.82 | SLC6A2 (0.48) | BCHESLC6A2CYP2D6 | |
| SCHEMBL8946157 | 0.82 | BCHE (0.55) | BCHESLC6A2MEN1KMT2A | |
| SCHEMBL8442522 | 0.79 | SLC6A2 (0.71) | BCHESLC6A2CYP2D6 | |
| SCHEMBL8946156 | 0.78 | SLC6A2 (0.49) | BCHESLC6A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276156-A | Antidepressants, treatment of Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-01-04 | — | — | US | claimed |
| EP-0509400-B1 | 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles, intermediates and a process for their preparation, and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-07-03 | — | — | EP | disclosed |
| US-5519131-A | CYCLIZATION OF HYDROXYALKYLAMINO COMPOUND IN THE PRESENCE OF STRONG BASE SUCH AS SODIUM HYDRIDE OR POTASSIUM TERT-BUTOXIDE | HOECHST MARION ROUSSEL INC. (US) | 1996-05-21 | — | — | US | disclosed |
| US-5276156-A | Antidepressants, treatment of Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-01-04 | — | — | US | disclosed |
| US-5214038-A | Cholinesterase inhibitors, antidepressants, cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0509400-A1 | 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles, intermediates and a process for their preparation, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-10-21 | — | — | EP | disclosed |