Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | HTR2B | P41595 | 2/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946675 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946681 | 1.00 | ALDH1A1 (0.36) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946512 | 0.80 | MAPT (0.40) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946508 | 0.80 | MAPT (0.40) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946516 | 0.80 | MAPT (0.40) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946281 | 0.76 | HTR2A (0.39) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946284 | 0.76 | HTR2A (0.39) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946289 | 0.76 | HTR2A (0.39) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946557 | 0.76 | MAPT (0.36) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| SCHEMBL8946552 | 0.76 | MAPT (0.36) | ALDH1A1KDM4ELMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |