Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13698843 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4EHSD17B10GAAPKM | |
| SCHEMBL8947051 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4EHSD17B10GAAPKM | |
| SCHEMBL8897336 | 0.74 | ALDH1A1 (0.33) | ALDH1A1KDM4EHSD17B10GAAPKM | |
| SCHEMBL8897329 | 0.74 | ALDH1A1 (0.33) | ALDH1A1KDM4EHSD17B10GAAPKM | |
| SCHEMBL8340733 | 0.67 | — | — | |
| SCHEMBL14131169 | 0.67 | — | — | |
| SCHEMBL1030123 | 0.67 | ALDH1A1 (0.41) | ALDH1A1KDM4EHSD17B10GAAPKM | |
| SCHEMBL13156428 | 0.65 | — | — | |
| SCHEMBL9167581 | 0.63 | ALDH1A1 (0.38) | ALDH1A1KDM4EHSD17B10GAAPKM | |
| SCHEMBL15918974 | 0.63 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |