Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19376949 | 0.86 | ALDH1A1 (0.64) | ALDH1A1MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL14564240 | 0.85 | MAPT (0.49) | ALDH1A1MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL8947257 | 0.85 | ALDH1A1 (0.66) | ALDH1A1MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL17204704 | 0.85 | NPC1 (0.65) | ALDH1A1MAPTTSHRLMNAMEN1 | |
| SCHEMBL15631020 | 0.83 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL8947325 | 0.81 | SMN1; SMN2 (0.57) | ALDH1A1MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL10231311 | 0.80 | HSP90AA1 (0.62) | ALDH1A1MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL31387585 | 0.80 | TSHR (0.66) | ALDH1A1MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL13495683 | 0.80 | TSHR (0.66) | ALDH1A1MAPTTSHRSMN1; SMN2LMNA | |
| SCHEMBL8947150 | 0.79 | GAA (0.67) | ALDH1A1MAPTTSHRSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |