Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966693 | 0.97 | ALDH1A1 (0.74) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947331 | 0.93 | ALDH1A1 (0.84) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL5966727 | 0.87 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947281 | 0.87 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947299 | 0.87 | ALDH1A1 (0.66) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947199 | 0.86 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947260 | 0.86 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947164 | 0.86 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947097 | 0.86 | ALDH1A1 (0.60) | ALDH1A1HPGDHSD11B1POLBHTT | |
| SCHEMBL8947183 | 0.86 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD11B1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |