Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | PGD | P52209 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL27528609 | 0.88 | TP53 (0.73) | TSHRALDH1A1TP53MAPTPTGS1 | |
| Lactic Acid SCHEMBL9493551 | 0.86 | TP53 (0.61) | TSHRALDH1A1TP53TET2CPT2 | |
| SCHEMBL11119131 | 0.85 | ALDH1A1 (0.69) | TSHRALDH1A1TP53TET2CPT2 | |
| Lactic Acid SCHEMBL28079130 | 0.85 | TP53 (0.69) | TSHRALDH1A1TP53MAPTPTGS1 | |
| Pivalate SCHEMBL11433335 | 0.85 | TP53 (0.69) | TSHRALDH1A1TP53MAPTPTGS1 | |
| Deaminohydroxyvaline SCHEMBL6444349 | 0.81 | TSHR (0.55) | TSHRALDH1A1TP53TET2CPT2 | |
| D-Lactic Acid SCHEMBL4371722 | 0.80 | TP53 (1.00) | TSHRALDH1A1TP53SLC7A5 | |
| Lactic Acid SCHEMBL9066423 | 0.80 | TP53 (1.00) | TSHRALDH1A1TP53SLC7A5 | |
| L-Lactic Acid SCHEMBL16958 | 0.80 | — | — | |
| Lactic Acid SCHEMBL9066424 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028999-A1 | Process for the preparation of antioxidant amides | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1981-05-20 | — | — | EP | claimed |
| CN-102802601-B | Tyr-Arg dipeptides is preventing the cosmetic applications of skin sagging | 赛德玛公司 | 2016-08-17 | — | — | CN | disclosed |
| US-5547988-A | Alleviating signs of dermatological aging with glycolic acid, lactic acid or citric acid | TRISTRATA TECHNOLOGY, INC. (US) | 1996-08-20 | — | — | US | disclosed |