Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947298 | 0.87 | ALDH1A1 (0.59) | ALDH1A1HPGDMLYCDMAPTGABRA1 | |
| SCHEMBL8947156 | 0.80 | MAPK1 (0.60) | MAPK1ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL8947157 | 0.80 | MAPK1 (0.53) | MAPK1ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL8947294 | 0.79 | MAPK1 (0.61) | MAPK1ALDH1A1HPGDTSHRL3MBTL1 | |
| SCHEMBL8947162 | 0.76 | HPGD (0.49) | MAPK1ALDH1A1HPGDTSHRL3MBTL1 | |
| SCHEMBL8947317 | 0.73 | ALDH1A1 (0.57) | MAPK1ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL9568720 | 0.72 | MAPK1 (0.43) | MAPK1ALDH1A1HPGDHSD11B1 | |
| SCHEMBL9568775 | 0.71 | NPSR1 (0.50) | MAPK1ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL8947128 | 0.71 | MAPK1 (0.53) | MAPK1ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL8118104 | 0.71 | MAPK1 (0.53) | MAPK1ALDH1A1HPGDTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |