Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL909725 | 0.85 | HSD17B10 (0.56) | ALOX15MAPK1HSD17B10POLBCYP2C19 | |
| SCHEMBL4290828 | 0.84 | KDM4E (0.59) | ALOX15MAPK1HSD17B10POLBCXCR2 | |
| SCHEMBL894741 | 0.83 | SIRT2 (0.70) | SIRT2MAPK1POLBCYP2C19ALDH1A1 | |
| SCHEMBL4959475 | 0.82 | ALDH1A1 (0.59) | ALOX15MAPK1HSD17B10POLBCYP2C19 | |
| SCHEMBL5509803 | 0.82 | SIRT2 (0.55) | SIRT2POLBCYP2C19ALDH1A1HPGD | |
| SCHEMBL16305428 | 0.82 | SIRT2 (0.55) | SIRT2HSD17B10POLBCYP2C19ALDH1A1 | |
| SCHEMBL7426825 | 0.81 | HSD17B10 (0.63) | ALOX15MAPK1HSD17B10POLBCXCR2 | |
| SCHEMBL22652375 | 0.78 | HSD17B10 (0.50) | SIRT2ALOX15MAPK1HSD17B10POLB | |
| SCHEMBL22289678 | 0.78 | SIRT2 (0.51) | SIRT2MAPK1POLBCYP2C19ALDH1A1 | |
| SCHEMBL28552726 | 0.78 | PDCD1 (0.63) | SIRT2MAPK1POLBCXCR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020227097-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |
| EP-2440034-A1 | HIGH OIL CONTENT PLANTS | Bayer BioScience N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20120084883-A1 | High Oil Content Plants | BAYER CROPSCIENCE N.V. (BE) | 2012-04-05 | — | — | US | disclosed |
| WO-2010142424-A1 | HIGH OIL CONTENT PLANTS | BAYER BIOSCIENCE N.V. (BE) | 2010-12-16 | — | — | WO | disclosed |