Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 9/20 | 0.64 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947812 | 0.85 | DPP4 (0.48) | DPP4TACR1 | |
| SCHEMBL17718404 | 0.83 | DPP4 (0.45) | DPP4 | |
| SCHEMBL8947990 | 0.83 | TACR1 (0.47) | DPP4TACR1 | |
| SCHEMBL5232770 | 0.78 | DPP4 (1.00) | DPP4TACR1KCNA5KCNH2 | |
| SCHEMBL9176574 | 0.76 | DPP4 (0.63) | DPP4TACR1MAPK8 | |
| SCHEMBL8947899 | 0.76 | DPP4 (1.00) | DPP4TACR1MAPK8CA1CA2 | |
| SCHEMBL8787724 | 0.75 | DPP4 (0.77) | DPP4TACR1MAPK8KCNA5KCNH2 | |
| SCHEMBL3621940 | 0.75 | DPP4 (0.62) | DPP4TACR1MAPK8KCNA5KCNH2 | |
| SCHEMBL8784994 | 0.73 | DPP4 (0.73) | DPP4TACR1MAPK8KCNA5KCNH2 | |
| SCHEMBL8948092 | 0.73 | DPP4 (0.73) | DPP4TACR1MAPK8KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527811-A | CALCIUM- AND SUBSTANCE P RECEPTOR-ANTAGONIST ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | claimed |