SCHEMBL8948725

SCHEMBL8948725

CC1(C)Oc2c(c(Cl)cc(Cl)c2-n2c(=O)cc(C(F)(F)F)[nH]c2=O)C1=O

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BCAT1 P54687 17/20 0.45
BCAT2 O15382 15/20 0.45
ALDH1A1 P00352 2/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8948502 0.78
SCHEMBL9379682 0.76 BCAT1 (0.54) BCAT1BCAT2ALDH1A1CYP2C9CYP2C19
SCHEMBL8783704 0.74 BCAT1 (0.46) BCAT1BCAT2ALDH1A1CYP2C9CYP2C19
SCHEMBL9376083 0.73 BCAT1 (0.53) BCAT1BCAT2ALDH1A1CYP2C9CYP2C19
SCHEMBL6966995 0.70 BCAT1 (0.50) BCAT1BCAT2ALDH1A1CYP2C9CYP2C19
SCHEMBL8948503 0.70
SCHEMBL8948505 0.70
SCHEMBL8948582 0.69
SCHEMBL8693580 0.68 BCAT1 (0.44) BCAT1BCAT2ALDH1A1CYP2C9CYP2C19
SCHEMBL9376465 0.68 BCAT1 (0.44) BCAT1BCAT2ALDH1A1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521147-A HERBICIDES FMC CORPORATION (US) 1996-05-28 US disclosed
WO-1995005079-A1 3-(BENZOFURAN-7-YL)-6-HALOALKYLURACILS FMC CORPORATION (US) 1995-02-23 WO disclosed