SCHEMBL8948911

SCHEMBL8948911

Cc1[c]noc1-c1ccc(Cl)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.39
NOTUM Q6P988 2/20 0.37
SMN1; SMN2 Q16637 4/20 0.35
NPC1 O15118 4/20 0.35
RAB9A P51151 4/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
ALDH1A1 P00352 6/20 0.35
TDO2 P48775 1/20 0.34
MAPT P10636 3/20 0.33
HPGD P15428 2/20 0.33
TSHR P16473 2/20 0.33
HSD17B10 Q99714 2/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 1/20 0.33
MAPK1 P28482 1/20 0.33
POLB P06746 1/20 0.33
CASP3 P42574 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL558586 0.80 BRD4 (0.38) NR1H4SMN1; SMN2NPC1RAB9AKMT2A
SCHEMBL15477789 0.73 NR1H4 (0.39) NR1H4NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL12377638 0.67 MAPT (0.48) NR1H4SMN1; SMN2NPC1MEN1KMT2A
SCHEMBL6482253 0.65
SCHEMBL5546174 0.63 CCR9 (0.44) NR1H4SMN1; SMN2NPC1RAB9AMEN1
SCHEMBL472411 0.63 GAA (0.49) NR1H4NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL472833 0.63 KDM4E (0.41) NR1H4NOTUMSMN1; SMN2NPC1RAB9A
SCHEMBL2818112 0.62 ALDH1A1 (0.41) NR1H4NOTUMSMN1; SMN2MEN1KMT2A
SCHEMBL3912888 0.61 CCNB2 (0.40) NOTUMMEN1KMT2ACYP1A2CYP2C19
SCHEMBL1435997 0.61 NPC1 (0.44) NR1H4NOTUMSMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5573999-A FUNGICIDES AND INSECTICIDES BASF AKTIENGESELLSCHAFT (DE) 1996-11-12 US disclosed
US-5538940-A FUNGICIDE, MITICIDE, INSECTICIDE BASF AKTIENGESELLSCHAFT (DE) 1996-07-23 US disclosed
EP-0668852-A1 SUBSTITUTED ORTHO-ETHENYL-PHENYL ACETIC ACID DERIVATIVES BASF Aktiengesellschaft (DE) 1995-08-30 EP disclosed
CN-1098713-A The ortho-ethenylphenylacetic acid derivatives that replaces BASF AG (DE) 1995-02-15 CN disclosed