Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 16/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | NME4 | O00746 | 1/20 | 0.43 |
| ▸ | GCDH | Q92947 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948996 | 0.89 | ITGB3 (0.43) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| SCHEMBL5230660 | 0.82 | HDAC3 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8949033 | 0.80 | ITGB3 (0.51) | ITGB3ITGA2BMAPK1HDAC3HDAC4 | |
| SCHEMBL8949063 | 0.77 | ITGB3 (0.47) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL8408094 | 0.76 | MAPK1 (0.68) | ITGB3ITGA2BMAPK1HDAC3HDAC4 | |
| SCHEMBL7275474 | 0.75 | ITGB3 (0.53) | ITGB3ITGA2B | |
| SCHEMBL8949335 | 0.75 | MAPK8 (0.47) | ITGB3ITGA2B | |
| SCHEMBL8409855 | 0.73 | MAPK1 (0.62) | ITGB3ITGA2BMAPK1 | |
| SCHEMBL8410637 | 0.73 | POLB (0.61) | ITGB3ITGA2BMAPK1 | |
| SCHEMBL8949087 | 0.73 | ITGB3 (0.55) | ITGB3ITGA2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |