Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA6 | P23280 | 4/20 | 0.49 |
| ▸ | CA7 | P43166 | 4/20 | 0.49 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949585 | 0.85 | KDM4E (0.63) | KDM4EALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL2897245 | 0.85 | KDM4E (0.72) | KDM4EALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL11628696 | 0.84 | KDM4E (0.75) | KDM4EALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL4763787 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL23574396 | 0.83 | KDM4E (0.64) | KDM4EALDH1A1L3MBTL1CA12CA1 | |
| SCHEMBL4376727 | 0.82 | KDM4E (0.76) | KDM4EALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL9199571 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1L3MBTL1CA12CA1 | |
| SCHEMBL8948970 | 0.80 | KDM6B (0.44) | — | |
| SCHEMBL11626689 | 0.76 | KDM4E (0.57) | KDM4EALDH1A1L3MBTL1CA12CA1 | |
| SCHEMBL11631180 | 0.75 | KDM4E (0.54) | KDM4EALDH1A1L3MBTL1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |