Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 7/20 | 0.58 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GGT1 | P19440 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9073220 | 0.91 | LTB4R (0.56) | LTB4RLTB4R2HTTKDM4EALDH1A1 | |
| SCHEMBL9075204 | 0.86 | LTB4R (0.62) | LTB4RLTB4R2 | |
| SCHEMBL6808531 | 0.85 | TSHR (0.54) | LTB4RLTB4R2ALDH1A1MEN1KMT2A | |
| SCHEMBL9858 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10HMGB1 | |
| SCHEMBL9074722 | 0.82 | LTB4R (0.54) | LTB4RLTB4R2HTTKDM4EALDH1A1 | |
| SCHEMBL9076064 | 0.82 | LTB4R (0.52) | LTB4RLTB4R2HTTKDM4EALDH1A1 | |
| SCHEMBL5206937 | 0.81 | DPP4 (0.44) | — | |
| SCHEMBL9074838 | 0.80 | LTB4R (0.60) | LTB4RLTB4R2 | |
| SCHEMBL1270519 | 0.80 | HTT (0.65) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11033915 | 0.80 | HTT (0.60) | LTB4RLTB4R2HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5552441-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |