Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | BCL9 | O00512 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15516165 | 0.91 | MAPT (0.59) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL7548121 | 0.83 | MAPT (0.51) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL9306479 | 0.82 | KMT2A (0.54) | MAPTCRHBPCRHR2L3MBTL1RAB9A | |
| SCHEMBL655938 | 0.81 | MAPT (0.58) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL11708706 | 0.80 | MAPT (0.56) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL30098369 | 0.80 | MAPT (0.56) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL3535210 | 0.80 | MAPT (0.56) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL7749276 | 0.80 | MAPT (0.53) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL3629791 | 0.80 | SMN1; SMN2 (0.56) | MAPTCRHBPCRHR2L3MBTL1HTR2A | |
| SCHEMBL6701306 | 0.78 | MAPT (0.52) | MAPTCRHBPCRHR2L3MBTL1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576167-A | Photographic element containing a stable aryloxypyrazolone coupler and process employing same | EASTMAN KODAK COMPANY (US) | 1996-11-19 | — | — | US | disclosed |