Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.77 |
| ▸ | NOS2 | P35228 | 5/20 | 0.51 |
| ▸ | NOS1 | P29475 | 4/20 | 0.51 |
| ▸ | NOS3 | P29474 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ARG2 | P78540 | 4/20 | 0.48 |
| ▸ | ARG1 | P05089 | 3/20 | 0.48 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL999246 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL209698 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL4583369 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL2400405 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL209697 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL23295178 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL124167 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL377041 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL2400402 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL2182542 | 0.94 | GSR (0.87) | GSRNOS2NOS1NOS3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484890-A | FACTOR VIII WITH STABILIZERS | JOHNSON ALAN J (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0651770-A1 | ANTIHEMOPHILIC FACTOR STABILIZATION | JOHNSON, Alan J. (US) | 1995-05-10 | — | — | EP | disclosed |
| EP-0651770-A4 | ANTIHEMOPHILIC FACTOR STABILIZATION. | JOHNSON ALAN J (US) | 1995-03-23 | — | — | EP | disclosed |
| US-5278289-A | Purification by ionic exchanging | JOHNSON ALAN J (US) | 1994-01-11 | — | — | US | disclosed |
| WO-1993010143-A1 | ANTIHEMOPHILIC FACTOR STABILIZATION | JOHNSON ALAN J (US) | 1993-05-27 | — | — | WO | disclosed |