Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.69 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EBP | Q15125 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8952089 | 1.00 | SIGMAR1 (0.69) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7430802 | 0.93 | SIGMAR1 (0.61) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL19193594 | 0.81 | SIGMAR1 (0.69) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7438015 | 0.81 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL169626 | 0.81 | SIGMAR1 (1.00) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8952178 | 0.81 | SIGMAR1 (0.65) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8952176 | 0.81 | SIGMAR1 (0.65) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9227594 | 0.80 | SIGMAR1 (0.70) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL17715877 | 0.79 | SIGMAR1 (0.65) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29353581 | 0.79 | SIGMAR1 (0.65) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552443-A | TREATMENT OF PSYCHOSIS, ANXIETY AND AS HYPOTENSIVE AGENTS | OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-09-03 | — | — | US | disclosed |
| US-5308869-A | TREATMENT OR PROPHYLAXIS OF ANXIETY IN AN ANIMAL | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION (US) | 1994-05-03 | — | — | US | disclosed |