Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14288449 | 0.82 | TLR8 (0.47) | TLR8KDM4EALDH1A1CNR1CNR2 | |
| SCHEMBL14288455 | 0.79 | TSHR (0.50) | TLR8ALDH1A1CNR1CNR2L3MBTL1 | |
| SCHEMBL10503713 | 0.76 | TSHR (0.38) | KDM4EALDH1A1GLAGAAHPGD | |
| Octane SCHEMBL9620215 | 0.74 | ESR2 (0.53) | KDM4EALDH1A1GAAHPGDL3MBTL1 | |
| Decane SCHEMBL9620442 | 0.74 | ESR2 (0.53) | KDM4EALDH1A1GAAHPGDL3MBTL1 | |
| SCHEMBL1779746 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL3595050 | 0.73 | STAT3 (0.49) | — | |
| SCHEMBL22749023 | 0.72 | CNR1 (0.48) | ALDH1A1CNR1CNR2 | |
| SCHEMBL13404301 | 0.70 | POLB (0.52) | KDM4EALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL11552875 | 0.70 | ALDH1A1 (0.35) | KDM4EALDH1A1GLAGAACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514816-A | REACTION OF DIFLUOROBENZO-1,3-DIOXOLE WITH METAL COMPOUNDS FOR INSECTICIDES | CIBA-GEIGY CORPORATION (US) | 1996-05-07 | — | — | US | disclosed |
| US-5496848-A | Process for the preparation of substituted difluorobenzo-1,3-dioxoles | CIBA-GEIGY CORPORATION (US) | 1996-03-05 | — | — | US | disclosed |
| US-5493032-A | INSECTICIDES, MICROBIOCIDES | CIBA-GEIGY CORPORATION (US) | 1996-02-20 | — | — | US | disclosed |
| US-5420301-A | Process for the preparation of substituted difluorobenzo-1,3-dioxoles | CIBA-GEIGY CORPORATION (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0333661-B1 | Process for the preparation of a pyrole derivative | CIBA GEIGY AG (CH) | 1994-04-27 | — | — | EP | disclosed |
| US-5281718-A | Reacting in one pot reaction 2,2-difluorobenzodioxole with an organometal compound or metal to form 4-metallo-2,2-difluorobenzodioxole, reacting with unsaturated nitrile, then with isocyanide | CIBA-GEIGY CORPORATION (US) | 1994-01-25 | — | — | US | disclosed |
| US-5194628-A | Reacting metallo-difluorobenzodioxole with unsaturated nitrile and then with sulfonylmethyl isocyanide | CIBA-GEIGY CORPORATION (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0333661-A2 | Process for the preparation of a pyrole derivative | CIBA-GEIGY AG (CH) | 1989-09-20 | — | — | EP | disclosed |