Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 7/20 | 0.39 |
| ▸ | TACR3 | P29371 | 4/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8952919 | 1.00 | HMGCR (0.39) | HMGCRTACR3SCN9APDE10ADHODH | |
| SCHEMBL8952837 | 0.87 | NR4A2 (0.32) | HMGCR | |
| SCHEMBL8952841 | 0.87 | NR4A2 (0.32) | HMGCR | |
| SCHEMBL8952868 | 0.86 | FABP4 (0.31) | HMGCR | |
| SCHEMBL8952860 | 0.86 | FABP4 (0.31) | HMGCR | |
| SCHEMBL8953145 | 0.86 | HMGCR (0.49) | HMGCR | |
| SCHEMBL8953146 | 0.86 | HMGCR (0.49) | HMGCR | |
| SCHEMBL8953026 | 0.85 | HMGCR (0.31) | HMGCR | |
| SCHEMBL8952904 | 0.85 | FABP4 (0.32) | HMGCR | |
| SCHEMBL8952912 | 0.85 | FABP4 (0.32) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |