SCHEMBL8952924

COP(=O)(C#Cc1c(-c2ccc(F)cc2)cc(-c2ccccc2)nc1C1CC1)C[C@H](CC(=O)O)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.55

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	SQOR	Q9Y6N5	2/20	0.37

▸	KDM4E	B2RXH2	2/20	0.35

▸	ALDH1A1	P00352	2/20	0.35

▸	LMNA	P02545	1/20	0.35

▸	HPGD	P15428	1/20	0.35

▸	NPSR1	Q6W5P4	1/20	0.35

▸	POLB	P06746	1/20	0.34

▸	MAPT	P10636	1/20	0.34

▸	CRHBP	P24387	1/20	0.34

▸	MAPK1	P28482	1/20	0.34

▸	CRHR2	Q13324	1/20	0.34

▸	TDP1	Q9NUW8	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8952876	0.89	SQOR (0.39)	SQORKDM4EALDH1A1LMNAHPGD
SCHEMBL8952979	0.88	—	—
SCHEMBL8953284	0.88	—	—
SCHEMBL8952807	0.86	—	—
SCHEMBL8952731	0.85	SQOR (0.42)	SQOR
SCHEMBL8953281	0.85	HMGCR (0.38)	—
SCHEMBL8952774	0.82	—	—
SCHEMBL8952998	0.82	—	—
SCHEMBL8952789	0.82	—	—
SCHEMBL8953047	0.81	—	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5506219-A	ANTICHOLESTEROL AND ANTILIPEMIC AGENTS	E. R. SQUIBB & SONS, INC. (US)	1996-04-09	—	—	US	disclosed
EP-0444533-A2	Quinoline and pyridine anchors for HMG-CoA reductase inhibitors	E.R. SQUIBB & SONS, INC. (US)	1991-09-04	—	—	EP	disclosed