Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28465641 | 0.96 | SLC15A2 (0.48) | SLC15A2GSRITGB3ITGA2BNOD1 | |
| Lysine SCHEMBL1050579 | 0.96 | SLC15A2 (0.48) | SLC15A2GSRITGB3ITGA2BNOD1 | |
| Lysine SCHEMBL28857873 | 0.95 | SLC15A2 (0.48) | SLC15A2GSRITGB3ITGA2BNOD1 | |
| Lysine SCHEMBL28518498 | 0.89 | GSR (0.43) | SLC15A2GSRITGB3ITGA2BNOD1 | |
| Histidine SCHEMBL18297977 | 0.89 | GSR (0.44) | SLC15A2GSRITGB3ITGA2BNOD1 | |
| SCHEMBL8832939 | 0.88 | SLC15A2 (0.64) | SLC15A2ITGB3ITGA2BFOLH1ERAP2 | |
| SCHEMBL3948446 | 0.88 | SLC15A2 (0.59) | SLC15A2ITGB3ITGA2BFOLH1 | |
| SCHEMBL3948444 | 0.88 | SLC15A2 (0.59) | SLC15A2ITGB3ITGA2BFOLH1 | |
| SCHEMBL10595108 | 0.88 | SLC15A2 (0.64) | SLC15A2ITGB3ITGA2BFOLH1ERAP2 | |
| SCHEMBL5598418 | 0.88 | SLC15A2 (0.64) | SLC15A2ITGB3ITGA2BFOLH1ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550183-A | Metal-peptide compositions and methods for stimulating hair growth | PROCYTE CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0495877-B1 | METHODS AND COMPOSITIONS FOR HEALING BONE | PROCYTE CORP (US) | 1995-03-22 | — | — | EP | disclosed |
| US-5348943-A | Copper complexes with derivatives of glycyl-histidyl-lysine | PROCYTE CORPORATION (US) | 1994-09-20 | — | — | US | disclosed |
| US-5214032-A | GHL-CU pharmaceutical compositions and compounds | PROCYTE CORPORATION (US) | 1993-05-25 | — | — | US | disclosed |
| US-5177061-A | Method for stimulating hair growth using GHL-Cu complexes | PROCYTE CORPORATION (US) | 1993-01-05 | — | — | US | disclosed |
| US-5135913-A | Increasing subcutaneous fat by administering copper-peptide complex | PROCYTE CORPORATION (US) | 1992-08-04 | — | — | US | disclosed |
| US-5120831-A | Hair growth stimulants | PROCYTE CORPORATION (US) | 1992-06-09 | — | — | US | disclosed |
| US-5059588-A | METHODS AND COMPOSITIONS FOR HEALING BONE USING GLY HIS LYS: COPPER | PROCYTE CORPORATION, INCORPORATED (US) | 1991-10-22 | — | — | US | disclosed |
| US-5023237-A | Using oligopeptide containing glycine, histidine, and lysine | PROCYTE CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |
| US-4877770-A | GLYCYL-HISTIDYL-LYSINE: COPPER WOUND HEALING AGENTS | PROCYTE CORPORATION (US) | 1989-10-31 | — | — | US | disclosed |
| US-4767753-A | GLYCYL-HISTIDYL-LYSINE DERIVATIVES | PROCYTE CORPORATION (US) | 1988-08-30 | — | — | US | disclosed |
| US-4665054-A | GLYCYL-HISTIDYL-LYSINE COPPER CHELATE | BIOHEAL, INC. (US) | 1987-05-12 | — | — | US | disclosed |