Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8954315 | 0.99 | TP53 (0.48) | TP53ALDH1A1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9530574 | 0.89 | MAPT (0.41) | TP53ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL7054174 | 0.88 | TP53 (0.48) | TP53 | |
| SCHEMBL7060199 | 0.83 | TP53 (0.57) | TP53ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL7059041 | 0.82 | TP53 (0.45) | TP53ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL8954114 | 0.82 | TP53 (0.47) | TP53ALDH1A1HSD17B10 | |
| SCHEMBL8954062 | 0.82 | TP53 (0.47) | TP53 | |
| SCHEMBL9472517 | 0.82 | ALDH1A1 (0.47) | TP53ALDH1A1HSD17B10MAPTCYP2C9 | |
| SCHEMBL9473390 | 0.82 | ALDH1A1 (0.43) | TP53ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL9472962 | 0.82 | TP53 (0.45) | TP53ALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530017-A | CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | SMITHKLINE BEECHAM CORP (US) | 1996-06-25 | — | — | US | disclosed |
| US-5444080-A | Hypotensive agents | SMITHKLINE BEECHAM CORPORATION (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002510-A1 | SUBSTITUTED [1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |