Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17104506 | 0.98 | PRSS1 (0.56) | PRSS1MAPTMEN1KMT2ATTR | |
| SCHEMBL29664575 | 0.98 | PRSS1 (0.56) | PRSS1MAPTMEN1KMT2ATTR | |
| SCHEMBL6651358 | 0.94 | PRSS1 (0.54) | PRSS1MAPTMEN1KMT2ATTR | |
| SCHEMBL29695817 | 0.89 | TSHR (0.59) | PRSS1MAPTMEN1KMT2ATTR | |
| SCHEMBL4101417 | 0.89 | TSHR (0.59) | PRSS1MAPTMEN1KMT2ATTR | |
| SCHEMBL8955606 | 0.88 | TSHR (0.52) | PRSS1TSHRTDP1ALDH1A1MAPK1 | |
| SCHEMBL30292262 | 0.88 | TSHR (0.55) | PRSS1MAPTKMT2ALMNATSHR | |
| SCHEMBL11221739 | 0.88 | MAPT (0.56) | PRSS1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL7907585 | 0.86 | NPC1 (0.59) | PRSS1MAPTMEN1KMT2ATTR | |
| SCHEMBL8372523 | 0.85 | PRSS1 (0.57) | PRSS1MAPTMEN1KMT2ATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516767-A | PRODRUG AS HYPOGLYCEMIC AGENT | SANDOZ LTD. (CH) | 1996-05-14 | — | — | US | disclosed |
| US-5412137-A | Hypoglycemic agents | SANDOZ LTD. (CH) | 1995-05-02 | — | — | US | disclosed |