SCHEMBL8955746

SCHEMBL8955746

CO[Si](CCc1ccc(N)cc1)(OC)OC

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 5/20 0.53
GFER P55789 1/20 0.52
TAAR1 Q96RJ0 1/20 0.45
MAOB P27338 6/20 0.45
MAOA P21397 2/20 0.45
TDP1 Q9NUW8 3/20 0.43
MAPK1 P28482 1/20 0.43
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 2/20 0.41
TSHR P16473 1/20 0.41
LOXL2 Q9Y4K0 1/20 0.39
RECQL P46063 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ATM Q13315 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL139733 0.89 TAAR1 (0.43) CYP19A1TAAR1MAOBKDM4E
SCHEMBL6879739 0.88 CYP19A1 (0.50) CYP19A1GFERTAAR1MAOBMAOA
SCHEMBL12190393 0.88 TAAR1 (0.61) TAAR1MAOBMAPK1ALDH1A1CYP3A4
SCHEMBL4291669 0.87 TAAR1 (0.41) CYP19A1TAAR1MAOBKDM4EATM
SCHEMBL9660429 0.83 TAAR1 (0.45) TAAR1MAOBLOXL2KDM4EATM
SCHEMBL27094924 0.83 MAOB (0.48) CYP19A1TAAR1MAOB
SCHEMBL8953980 0.82 GFER (0.50) CYP19A1GFERTAAR1MAOBMAOA
SCHEMBL8954118 0.82 GFER (0.50) CYP19A1GFERTAAR1MAOBMAOA
SCHEMBL11648990 0.81 TAAR1 (0.46) TAAR1MAOB
SCHEMBL5485070 0.81 TAAR1 (0.46) TAAR1MAOBTDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210017420-A1 STRUCTURE BODY, SENSOR, AND METHOD FOR PRODUCING STRUCTURE BODY DENSO CORPORATION (JP) 2021-01-21 US disclosed
US-5536584-A SEMICONDUCTOR INTEGRATED CIRCUIT, TRANSISTOR AND A THIN FILM MULTILEVEL WIRING BOARD USES SURFACE PROTECTIVE COATING OF POLYIMIDE HITACHI, LTD. (JP) 1996-07-16 US disclosed
US-5272247-A Polyimide precursor, cured product thereof, and processes for producing them HITACHI, LTD. (JP) 1993-12-21 US disclosed
US-4118367-A WITH SILICA FROM NOVEL AZO-SILANE COUPLING AGENT WHICH DOES NOT DEPEND ON VULCANIZATION TO REACT; ABRASION AND SCORCH RESISTANT THE MALAYSIAN RUBBER PRODUCERS RESEARCH ASSOCIATION (GB) 1978-10-03 US disclosed