Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 2/20 | 0.68 |
| ▸ | PGK1 | P00558 | 2/20 | 0.54 |
| ▸ | PGK2 | P07205 | 2/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427108 | 0.87 | ACP3 (0.60) | ACP3PGK1PGK2IDO1THRB | |
| SCHEMBL1832383 | 0.87 | ACP3 (0.60) | ACP3PGK1PGK2IDO1THRB | |
| SCHEMBL8957015 | 0.84 | ACP3 (0.57) | ACP3PGK1PGK2IDO1THRB | |
| SCHEMBL4994252 | 0.84 | ACP3 (0.51) | ACP3PGK1PGK2THRBMAOB | |
| SCHEMBL17969143 | 0.82 | ACP3 (0.59) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL9551651 | 0.82 | ACP3 (0.56) | ACP3PGK1PGK2IDO1THRB | |
| SCHEMBL8957011 | 0.82 | ACP3 (0.55) | ACP3PGK1PGK2IDO1THRB | |
| SCHEMBL8938041 | 0.81 | ACP3 (0.66) | ACP3PGK1PGK2IDO1MAOB | |
| SCHEMBL30438454 | 0.81 | ACP3 (1.00) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL8938031 | 0.81 | ACP3 (1.00) | ACP3PGK1PGK2IDO1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532226-A | FOR INCREASING BONE FORMATION AND BONE MASS IN MAMMALS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-07-02 | — | — | US | claimed |
| CN-1070408-A | The trifluoromethyl benzyl phosphonic acid ester that is used for the treatment of osteoporosis | ORTHO PHARMA CORP (US) | 1993-03-31 | — | — | CN | claimed |
| EP-0524023-A1 | Trifluoromethylbenzylphosphonates useful in treating osteoporosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-01-20 | — | — | EP | claimed |
| US-5532226-A | FOR INCREASING BONE FORMATION AND BONE MASS IN MAMMALS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| US-5300687-A | Trifluoromethylbenzylphosphonates useful in treating osteoporosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-04-05 | — | — | US | disclosed |
| CN-1070408-A | The trifluoromethyl benzyl phosphonic acid ester that is used for the treatment of osteoporosis | ORTHO PHARMA CORP (US) | 1993-03-31 | — | — | CN | disclosed |
| EP-0524023-A1 | Trifluoromethylbenzylphosphonates useful in treating osteoporosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-01-20 | — | — | EP | disclosed |