Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 1/20 | 0.57 |
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | PGK2 | P07205 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1832383 | 0.85 | ACP3 (0.60) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL29427108 | 0.85 | ACP3 (0.60) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL8956972 | 0.84 | ACP3 (0.68) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL8957011 | 0.83 | ACP3 (0.55) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL27831115 | 0.78 | IDO1 (0.54) | ACP3IDO1HTR2AHTR2BHTR2C | |
| SCHEMBL8957013 | 0.77 | ACP3 (0.50) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL1833514 | 0.75 | ACP3 (0.48) | ACP3IDO1HTR2AHTR2BHTR2C | |
| SCHEMBL8957047 | 0.75 | ACP3 (0.48) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL8957026 | 0.75 | ACP3 (0.48) | ACP3PGK1PGK2IDO1HTR2A | |
| SCHEMBL8957041 | 0.75 | ACP3 (0.48) | ACP3PGK1PGK2IDO1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532226-A | FOR INCREASING BONE FORMATION AND BONE MASS IN MAMMALS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| US-5300687-A | Trifluoromethylbenzylphosphonates useful in treating osteoporosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0524023-A1 | Trifluoromethylbenzylphosphonates useful in treating osteoporosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-01-20 | — | — | EP | disclosed |