Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10717585 | 0.84 | CES1 (0.47) | MAPK1LMNACES1HTTKDM4E | |
| SCHEMBL32665929 | 0.84 | CES1 (0.47) | MAPK1LMNACES1HTTKDM4E | |
| SCHEMBL8576590 | 0.80 | HPGD (0.47) | HPGDMAPK1LMNAGAAL3MBTL1 | |
| SCHEMBL9747292 | 0.79 | CES1 (0.42) | MAPK1LMNACES1HTTKDM4E | |
| SCHEMBL8182295 | 0.78 | CES1 (0.41) | HPGDMAPK1CES1HTTKDM4E | |
| SCHEMBL11129913 | 0.78 | CES1 (0.41) | MAPK1CES1HTTKDM4EIDO1 | |
| SCHEMBL32665935 | 0.78 | PDK2 (0.42) | HPGDMAPK1LMNACES1HTT | |
| SCHEMBL28094548 | 0.77 | HPGD (0.52) | HPGDLMNAGAAL3MBTL1CES1 | |
| SCHEMBL3266778 | 0.77 | TSHR (0.41) | MAPK1LMNAL3MBTL1CES1HTT | |
| SCHEMBL9668760 | 0.76 | GAA (0.55) | HPGDLMNAGAAL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498722-A | HYPOTENSIVES | GLAXO GROUP (GB) | 1996-03-12 | — | — | US | disclosed |