SCHEMBL8957598

SCHEMBL8957598

O=C(O)CC1CC1(F)F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23095576 1.00
SCHEMBL8957597 1.00
SCHEMBL31704162 0.81 GRM2 (0.36)
SCHEMBL30877178 0.80 GRM2 (0.34)
SCHEMBL17316739 0.80 GRM2 (0.43)
SCHEMBL9390066 0.80
SCHEMBL25373788 0.78 GRM2 (0.47)
SCHEMBL8990195 0.77
SCHEMBL31119430 0.77
SCHEMBL19014082 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578595-A PESTICIDES CIBA-GEIGY CORPORATION (US) 1996-11-26 US claimed
EP-0467840-A2 Derivatives of cyclopropyl acetic acid CIBA-GEIGY AG (CH) 1992-01-22 EP claimed
EP-4745125-A1 PESTICIDALLY-ACTIVE 2,2-DIHALOCYCLOPROPYL COMPOUNDS Syngenta Crop Protection AG (CH) 2026-05-20 EP disclosed
US-20260055116-A1 SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS KARUNA THERAPEUTICS INC (US) 2026-02-26 US disclosed
EP-4653438-A1 MACROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, AND USE THEREOF Genfleet Therapeutics (Shanghai) Inc. (CN) 2025-11-26 EP disclosed
US-12421242-B2 Substituted tetrahydropyrrolo-pyridinone compounds and their use in treating medical conditions Karuna Therapeutics, Inc. (US) 2025-09-23 US disclosed
EP-4143195-B1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 JANSSEN PHARMACEUTICA NV (BE) 2025-05-21 EP disclosed
CN-115867348-B Imidazopyrimidines as IL-17 modulators 詹森药业有限公司 2025-05-06 CN disclosed
WO-2025064683-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-03-27 WO disclosed
US-20250059157-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2025-02-20 US disclosed
US-20240383876-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2024-11-21 US disclosed
US-5326901-A 3-butenoic acid derivatives as intermediates for pesticides CIBA-GEIGY CORPORATION (US) 1994-07-05 US disclosed
EP-0318425-B1 DERIVATIVES OF 2,2-DIFLUORCYCLOPROPYL ETHANE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN PEST CONTROL SCHERING AKTIENGESELLSCHAFT (DE) 1992-03-18 EP disclosed
US-5089662-A Miticides SCHERING AKTIENGESELLSCHAFT (DE) 1992-02-18 US disclosed
EP-0467840-A2 Derivatives of cyclopropyl acetic acid CIBA-GEIGY AG (CH) 1992-01-22 EP disclosed
EP-0467840-A2 Derivatives of cyclopropyl acetic acid CIBA-GEIGY AG (CH) 1992-01-22 EP disclosed
US-5071869-A 2-FLUOROCYCLOPROPYLACETIC ACID ESTERS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES SCHERING AKTIENGESELLSCHAFT (DE) 1991-12-10 US disclosed
EP-0430380-A2 2-Fluorocyclopropylacetic acid esters, processes for their preparation and their use as pesticides SCHERING AKTIENGESELLSCHAFT (DE) 1991-06-05 EP disclosed
US-4983630-A Insecticides, miticides SCHERING AKTIENGESELLSCHAFT (DE) 1991-01-08 US disclosed
EP-0318425-A1 Derivatives of 2,2-difluorcyclopropyl ethane, process for their preparation and their use in pest control SCHERING AKTIENGESELLSCHAFT (DE) 1989-05-31 EP disclosed