Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958909 | 1.00 | NOD2 (0.47) | NOD2NOD1LMNAKDM4ETSHR | |
| SCHEMBL8752560 | 0.96 | NOD2 (0.47) | NOD2NOD1LMNAKDM4ETSHR | |
| SCHEMBL8752556 | 0.96 | NOD2 (0.47) | NOD2NOD1LMNAKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL27315758 | 0.95 | NOD2 (0.46) | NOD2NOD1LMNAKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL8752575 | 0.95 | NOD2 (0.46) | NOD2NOD1LMNAKDM4ETSHR | |
| SCHEMBL8958572 | 0.93 | NOD2 (0.42) | NOD2NOD1LMNAKDM4ETSHR | |
| SCHEMBL8958576 | 0.93 | NOD2 (0.42) | NOD2NOD1LMNAKDM4ETSHR | |
| SCHEMBL8958744 | 0.91 | KDM4E (0.44) | NOD2NOD1LMNAKDM4ETSHR | |
| SCHEMBL8958748 | 0.91 | KDM4E (0.44) | NOD2NOD1LMNAKDM4ETSHR | |
| SCHEMBL8752572 | 0.90 | NOD2 (0.46) | NOD2NOD1LMNAKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519048-A | 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof | MERRELL PHARMACEUTICALS INC. (US) | 1996-05-21 | — | — | US | disclosed |