Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 15/20 | 0.71 |
| ▸ | HTR2A | P28223 | 13/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959539 | 1.00 | HTR2C (0.71) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959648 | 1.00 | HTR2C (0.71) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959629 | 0.88 | HTR2C (0.56) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959836 | 0.88 | HTR2C (0.74) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959895 | 0.88 | HTR2C (0.74) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959844 | 0.88 | HTR2C (0.74) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959583 | 0.88 | HTR2C (0.74) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959641 | 0.88 | HTR2C (0.56) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959579 | 0.88 | HTR2C (0.74) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959826 | 0.85 | HTR2C (0.54) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |