Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.71 |
| ▸ | HTR2A | P28223 | 9/20 | 0.71 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959650 | 1.00 | HTR2C (0.71) | HTR2CHTR2APRMT5HTR7P2RX7 | |
| SCHEMBL8959709 | 0.87 | HTR2C (0.71) | HTR2CHTR2APRMT5KDM4EHPGD | |
| SCHEMBL8959717 | 0.87 | HTR2C (0.71) | HTR2CHTR2APRMT5KDM4EHPGD | |
| SCHEMBL25154150 | 0.86 | HTR2C (0.76) | HTR2CHTR2APRMT5HTR7P2RX7 | |
| SCHEMBL9230485 | 0.83 | HTR2C (1.00) | HTR2CHTR2APRMT5HTR7CYP1A2 | |
| SCHEMBL9230483 | 0.83 | HTR2C (1.00) | HTR2CHTR2APRMT5HTR7CYP1A2 | |
| SCHEMBL7253595 | 0.82 | HTR2C (0.55) | HTR2CHTR2APRMT5HTR7 | |
| SCHEMBL7253587 | 0.82 | HTR2C (0.55) | HTR2CHTR2APRMT5HTR7 | |
| SCHEMBL8959921 | 0.82 | HTR2C (0.72) | HTR2CHTR2APRMT5HTR7P2RX7 | |
| SCHEMBL7676168 | 0.82 | HTR2C (0.55) | HTR2CHTR2APRMT5HTR7CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |