Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.48 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.48 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.48 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31028218 | 0.84 | CHRM4 (0.64) | CHRM4ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL2970071 | 0.84 | CHRM4 (0.64) | CHRM4ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL8959854 | 0.83 | CYP2D6 (0.50) | CYP2D6ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL11191118 | 0.82 | KMT2A (0.56) | CYP2D6ALDH1A1OPRL1TSHRMEN1 | |
| SCHEMBL4265747 | 0.80 | CYP2D6 (0.58) | CYP2D6ALDH1A1OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL9310958 | 0.79 | CYP2D6 (0.46) | CYP2D6ALDH1A1OPRL1TSHRMEN1 | |
| SCHEMBL31559216 | 0.79 | CYP2D6 (0.46) | CYP2D6ALDH1A1OPRL1TSHRKMT2A | |
| SCHEMBL9046812 | 0.79 | KDM4E (0.51) | CYP2D6ALDH1A1OPRL1TSHRKMT2A | |
| SCHEMBL5242779 | 0.78 | OPRL1 (0.67) | CYP2D6ALDH1A1OPRL1TSHRKMT2A | |
| SCHEMBL3081018 | 0.77 | ALDH1A1 (0.60) | CYP2D6ALDH1A1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372776-B1 | Arylpiperidine derivatives | PFIZER (US) | 1996-09-25 | — | — | EP | disclosed |
| EP-0691956-A1 | 3-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEDATIVES | LABORATOIRE L. LAFON (FR) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022827-A1 | 3-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEDATIVES | LABORATOIRE L. LAFON (FR) | 1994-10-13 | — | — | WO | disclosed |
| US-5294619-A | N-(nitrogen-containing heterocyclylalkyl-phenyl-piperidines | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5153206-A | Neuroleptic agents for treating psychological disorders | PFIZER INC. (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0372776-A2 | Arylpiperidine derivatives | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |