Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13974634 | 0.98 | FFAR1 (0.42) | FFAR1RAB9ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL14557463 | 0.91 | FFAR1 (0.52) | FFAR1RAB9ASMN1; SMN2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL2872667 | 0.90 | SLC22A2 (0.47) | FFAR1RAB9ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL29018991 | 0.90 | BCHE (0.43) | FFAR1LMNACYP1A2MAPTMEN1 | |
| SCHEMBL13021356 | 0.90 | MAPT (0.44) | FFAR1RAB9ASMN1; SMN2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL29033506 | 0.89 | BCHE (0.42) | FFAR1LMNACYP1A2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL29033520 | 0.89 | BCHE (0.42) | FFAR1LMNACYP1A2MAPTMEN1 | |
| SCHEMBL18883321 | 0.88 | SLC22A2 (0.48) | FFAR1RAB9ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL12905328 | 0.88 | CYP1A2 (0.42) | FFAR1RAB9ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL31481271 | 0.84 | MAPT (0.47) | FFAR1RAB9ASMN1; SMN2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483098-B1 | Processs for producing N-phosphonomethylglycine | MONSANTO CO (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0412074-B1 | Process for producing N-Phosphonomethylglycine | MONSANTO CO (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0483098-A1 | Processs for producing N-phosphonomethylglycine | MONSANTO COMPANY (US) | 1992-04-29 | — | — | EP | disclosed |
| US-5061820-A | CATALYTIC OXIDATION OF N-PHOSPHONOMETHYLIMINODIACETIC ACID | MONSANTO COMPANY (US) | 1991-10-29 | — | — | US | disclosed |
| EP-0412074-A2 | Process for producing N-Phosphonomethylglycine | MONSANTO COMPANY (US) | 1991-02-06 | — | — | EP | disclosed |
| US-4952723-A | CATALYTIC OXIDATION OF N-PHOSPHONOMETHYLIMINODIACETIC ACID | MONSANTO COMPANY (US) | 1990-08-28 | — | — | US | disclosed |