Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.45 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.45 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.45 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373667 | 0.98 | OPRM1 (0.48) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL144177 | 0.95 | OPRM1 (0.50) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL479112 | 0.95 | OPRM1 (0.47) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL334991 | 0.93 | OPRM1 (0.49) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL2795989 | 0.91 | OPRM1 (0.44) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL29151407 | 0.89 | OPRM1 (0.49) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL16104361 | 0.87 | CARM1 (0.55) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL17195397 | 0.87 | HTT (0.56) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8021687 | 0.87 | TSHR (0.59) | OPRM1TSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL11197923 | 0.87 | HRH3 (0.59) | OPRM1OPRD1TSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358609-B1 | Parasiticide compounds | CIBA GEIGY AG (CH) | 1996-07-24 | — | — | EP | disclosed |
| EP-0441747-B1 | Microbicide agent | CIBA GEIGY AG (CH) | 1996-07-03 | — | — | EP | disclosed |
| EP-0457726-B1 | 2-Anilinopyrimidine derivatives as pesticides | CIBA GEIGY AG (CH) | 1996-02-07 | — | — | EP | disclosed |
| US-5439912-A | Plant fungicide, insecticide, pesticide | CIBA-GEIGY CORPORATION (US) | 1995-08-08 | — | — | US | disclosed |
| US-5322853-A | For controlling or preventing an attack on plants by phytopathogenic microorganisms | CIBA-GEIGY CORPORATION (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0462931-B1 | Benzotriazole-1-sulfonyl derivatives with microbicidal properties | CIBA GEIGY AG (CH) | 1994-04-13 | — | — | EP | disclosed |
| EP-0295210-B1 | MICROBICIDES | CIBA-GEIGY AG (CH) | 1993-08-04 | — | — | EP | disclosed |
| EP-0310550-B1 | PESTICIDE | CIBA-GEIGY AG (CH) | 1993-05-26 | — | — | EP | disclosed |
| US-5175293-A | Substituted 2-aminopyrimidine derivatives | CIBA-GEIGY CORPORATION (US) | 1992-12-29 | — | — | US | disclosed |
| US-5153200-A | Insecticides, microbiocides | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0457727-A1 | Pesticides | CIBA-GEIGY AG (CH) | 1991-11-21 | — | — | EP | disclosed |
| EP-0457726-A1 | 2-Anilinopyrimidine derivatives as pesticides | CIBA-GEIGY AG (CH) | 1991-11-21 | — | — | EP | disclosed |
| EP-0445074-A1 | N-(2,6-Dinitro-3-chloro-4-trifluoromethylphenyl)-4-amino-6-fluoropyrimidine derivatives and their use as microbicidal agents | CIBA-GEIGY AG (CH) | 1991-09-04 | — | — | EP | disclosed |
| EP-0441747-A2 | Microbicide agent | CIBA-GEIGY AG (CH) | 1991-08-14 | — | — | EP | disclosed |
| US-4997941-A | Insecticides for plant protection, also used as fungicides | CIBA-GEIGY CORPORATION (US) | 1991-03-05 | — | — | US | disclosed |
| US-4931560-A | FUNGICIDES | CIBA-GEIGY CORPORATION (US) | 1990-06-05 | — | — | US | disclosed |
| EP-0358609-A2 | Parasiticide compounds | CIBA-GEIGY AG (CH) | 1990-03-14 | — | — | EP | disclosed |
| US-4897396-A | AGRICULTURAL INSECTICIDES, PESTICIDES AND FUNGICIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0310550-A1 | Pesticide | CIBA-GEIGY AG (CH) | 1989-04-05 | — | — | EP | disclosed |
| EP-0295210-A1 | Microbicides | CIBA-GEIGY AG (CH) | 1988-12-14 | — | — | EP | disclosed |