Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 2/20 | 0.44 |
| ▸ | F3 | P13726 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | TERT | O14746 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8961885 | 0.94 | FAAH (0.47) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL8961891 | 0.93 | FAAH (0.50) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL8961979 | 0.93 | FAAH (0.50) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL8961924 | 0.93 | FAAH (0.50) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL8961848 | 0.93 | FAAH (0.50) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL8961953 | 0.88 | HCAR2 (0.35) | FAAHMAPTATMPTGS1 | |
| SCHEMBL4772460 | 0.83 | TSHR (0.58) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL869635 | 0.82 | F7 (0.48) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL869633 | 0.82 | F7 (0.48) | F7F3FAAHTERTPTPN1 | |
| SCHEMBL4651888 | 0.81 | ATM (0.53) | F7F3FAAHTERTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523543-B1 | Chiral piperazine derivatives | HOFFMANN LA ROCHE (CH) | 1996-02-07 | — | — | EP | disclosed |
| US-5356559-A | Optically active piperazinyl derivatives as liquid crystals | HOFFMANN-LA ROCHE INC. (US) | 1994-10-18 | — | — | US | disclosed |
| EP-0523543-A1 | Chiral piperazine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-01-20 | — | — | EP | disclosed |