Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.72 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.51 |
| ▸ | CDC25B | P30305 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962019 | 1.00 | PTGS2 (0.72) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8962024 | 1.00 | PTGS2 (0.72) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8962125 | 1.00 | PTGS2 (0.72) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8962134 | 1.00 | PTGS2 (0.72) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8962129 | 0.86 | PTGS2 (0.72) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8961985 | 0.86 | PTGS2 (0.72) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8962104 | 0.82 | PTGS2 (0.69) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8962105 | 0.82 | PTGS2 (0.69) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL8962110 | 0.82 | PTGS2 (0.69) | PTGS2PTGS1PTPN1CDC25BGAA | |
| SCHEMBL29369078 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1GAAALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449216-B1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER LAMBERT CO (US) | 1996-02-07 | — | — | EP | claimed |
| US-5143928-A | Inhibitors of cyclooxygenase and lipoxygenase | WARNER-LAMBERT COMPANY (US) | 1992-09-01 | — | — | US | claimed |