Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.78 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | EEF2K | O00418 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962137 | 1.00 | PTGS2 (0.78) | PTGS2PTGS1ALOX5POLBEEF2K | |
| SCHEMBL8961989 | 0.91 | PTGS2 (0.76) | PTGS2PTGS1ALOX5POLBEEF2K | |
| SCHEMBL8961992 | 0.88 | PTGS2 (1.00) | PTGS2PTGS1ALOX5POLBEEF2K | |
| Hydrochloric Acid SCHEMBL7702114 | 0.87 | PTGS2 (0.98) | PTGS2PTGS1ALOX5POLBEEF2K | |
| SCHEMBL7698980 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1ALOX5EEF2KSRC | |
| SCHEMBL8961923 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1ALOX5EEF2KSRC | |
| SCHEMBL8962093 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1ALOX5EEF2KSRC | |
| Darbufelone SCHEMBL2682812 | 0.81 | PTGS1 (1.00) | PTGS2PTGS1ALOX5POLB | |
| Darbufelone SCHEMBL2682810 | 0.81 | PTGS1 (1.00) | PTGS2PTGS1ALOX5POLB | |
| SCHEMBL8962085 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1ALOX5EEF2KSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449216-B1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER LAMBERT CO (US) | 1996-02-07 | — | — | EP | claimed |
| EP-0449216-A1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | claimed |