Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9063039 | 0.76 | MAPT (0.40) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL1122340 | 0.76 | MAPT (0.43) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL8962453 | 0.74 | MAPT (0.42) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL8963355 | 0.74 | MAPT (0.44) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL9063047 | 0.72 | MAPT (0.40) | KDM4ETP53CYP3A4MAPTALOX15 | |
| SCHEMBL8962767 | 0.72 | — | — | |
| SCHEMBL8962505 | 0.72 | — | — | |
| SCHEMBL8962555 | 0.72 | — | — | |
| SCHEMBL8962527 | 0.72 | — | — | |
| SCHEMBL8962482 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996019446-A1 | β-CARBOXY SULFONAMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | claimed |
| US-5491170-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-02-13 | — | — | US | disclosed |