Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9063039 | 0.88 | MAPT (0.40) | MAPTLMNAKDM4ETP53CYP3A4 | |
| SCHEMBL9063047 | 0.86 | MAPT (0.40) | MAPTLMNAKDM4ETP53CYP3A4 | |
| SCHEMBL8963355 | 0.85 | MAPT (0.44) | MAPTLMNAL3MBTL1KDM4ETP53 | |
| SCHEMBL8962452 | 0.76 | KDM4E (0.48) | MAPTKDM4ETP53CYP3A4ALOX15 | |
| SCHEMBL7085059 | 0.76 | CYP3A4 (0.41) | MAPTLMNAKDM4ETP53CYP3A4 | |
| SCHEMBL28701074 | 0.76 | ALDH1A1 (0.67) | L3MBTL1KDM4ECYP3A4PTPN1ALDH1A1 | |
| SCHEMBL829810 | 0.74 | CA1 (0.54) | LMNAL3MBTL1KDM4ETSHRALDH1A1 | |
| SCHEMBL2338643 | 0.73 | PTPN1 (0.43) | MAPTCYP3A4PTPN1HSD17B10ALDH1A1 | |
| SCHEMBL9063053 | 0.73 | MEN1 (0.37) | MAPTLMNAKDM4ETP53CYP3A4 | |
| SCHEMBL831093 | 0.73 | GAA (0.51) | LMNAL3MBTL1TP53ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |