SCHEMBL8962591

SCHEMBL8962591

Cc1[nH]cnc1CC1CCc2c(c3cccc4c3n2CCC4)C1=O

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.43
HPGD P15428 3/20 0.43
ALDH1A1 P00352 2/20 0.43
USP2 O75604 1/20 0.43
MCL1 Q07820 1/20 0.39
CYP1A2 P05177 2/20 0.38
HTR2A P28223 2/20 0.38
HTR2C P28335 2/20 0.38
CYP3A4 P08684 1/20 0.38
ADRA2C P18825 1/20 0.38
ADRA1A P35348 1/20 0.38
HTR2B P41595 1/20 0.38
HTR3A P46098 1/20 0.38
KCNH2 Q12809 1/20 0.38
CASP6 P55212 1/20 0.38
KDM4E B2RXH2 3/20 0.37
LMNA P02545 2/20 0.37
CD44 P16070 2/20 0.36
MAPT P10636 1/20 0.36
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7302176 0.97 HSD17B10 (0.40) HSD17B10HPGDALDH1A1USP2MCL1
Fumaric Acid SCHEMBL7322067 0.94 MCL1 (0.39) HSD17B10HPGDALDH1A1USP2MCL1
Maleic Acid SCHEMBL7322062 0.94 MCL1 (0.39) HSD17B10HPGDALDH1A1USP2MCL1
SCHEMBL7304185 0.85 CYP1A2 (0.32) HSD17B10HPGDALDH1A1USP2CYP1A2
Hydrochloric Acid SCHEMBL7302142 0.83 CASP6 (0.40) CYP1A2HTR2AHTR2CCYP3A4ADRA2C
Hydrochloric Acid SCHEMBL7298417 0.82 CASP6 (0.39) CYP1A2HTR2AHTR2CCYP3A4ADRA2C
SCHEMBL9090622 0.79 CYP1A2 (0.62) HSD17B10HPGDALDH1A1USP2CYP1A2
SCHEMBL9366393 0.79 CYP3A4 (0.43) CYP1A2HTR2AHTR2CCYP3A4ADRA2C
SCHEMBL9088979 0.79 CYP1A2 (0.57) HSD17B10HPGDALDH1A1USP2CYP1A2
SCHEMBL9585427 0.78 CYP1A2 (0.55) HSD17B10HPGDALDH1A1USP2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5530008-A USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA SANDOZ LTD. (CH) 1996-06-25 US claimed
EP-0422154-B1 THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS SANDOZ AG (AT) 1993-12-01 EP claimed
US-5045545-A [(Imidazol-4(and 5)-yl)methyl] tetracyclic ketones having 5-HT3 antagonist activity GLAXO GROUP LIMITED (GB) 1991-09-03 US claimed
US-5530008-A USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA SANDOZ LTD. (CH) 1996-06-25 US disclosed
US-5045545-A [(Imidazol-4(and 5)-yl)methyl] tetracyclic ketones having 5-HT3 antagonist activity GLAXO GROUP LIMITED (GB) 1991-09-03 US disclosed