Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PPID | Q08752 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4077561 | 0.94 | ATM (0.48) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL10487028 | 0.73 | ATM (0.54) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3804291 | 0.70 | ATM (0.50) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL341470 | 0.70 | SMN1; SMN2 (0.39) | DPP4ALDH1A1SMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL13558721 | 0.70 | ATM (0.50) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1226363 | 0.70 | ATM (0.50) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL16373575 | 0.68 | DPP4 (0.49) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL19512431 | 0.68 | ATM (0.48) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2907861 | 0.68 | ATM (0.48) | ATMDPP4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3942505 | 0.68 | L3MBTL1 (0.36) | ALDH1A1SMN1; SMN2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101522201-B | The solid citrate of DPP-IV inhibitor and tartrate | HANGZHOU HUADONG MEDICINE GROUP PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. (CN) | 2015-08-19 | — | — | CN | disclosed |
| CN-101522201-B | The solid citrate of DPP-IV inhibitor and tartrate | HANGZHOU HUADONG MEDICINE GROUP PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. (CN) | 2015-08-19 | — | — | CN | disclosed |
| US-8748457-B2 | 2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent DPP-IV inhibitors | LUPIN LIMITED (IN) | 2014-06-10 | — | — | US | disclosed |
| US-8338450-B2 | Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors | LUPIN LIMITED (IN) | 2012-12-25 | — | — | US | disclosed |
| US-8299271-B2 | Solid tartrate salts of DPP-IV inhibitors | PHENOMIX CORPORATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-8299271-B2 | Solid tartrate salts of DPP-IV inhibitors | PHENOMIX CORPORATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120082635-A1 | 2-AMINO-2- [8-(DIMETHYL CARBAMOYL)- 8-AZA- BICYCLO [3.2.1] OCT-3-YL]-EXO- ETHANOYL DERIVATIVES AS POTENT DPP-IV INHIBITORS | LUPIN LIMITED (IN) | 2012-04-05 | — | — | US | disclosed |
| US-7906658-B2 | Antidiabetic agents | PHENOMIX CORPORATION (US) | 2011-03-15 | — | — | US | disclosed |
| US-7884217-B2 | Antidiabetic agents | PHENOMIX CORPORATION (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884217-B2 | Antidiabetic agents | PHENOMIX CORPORATION (US) | 2011-02-08 | — | — | US | disclosed |
| WO-2008027273-A2 | SOLID CITRATE AND TARTRATE SALTS OF DPP-IV INHIBITORS | PHENOMIX CORPORATION (US) | 2008-03-06 | — | — | WO | disclosed |
| WO-2008027273-A2 | SOLID CITRATE AND TARTRATE SALTS OF DPP-IV INHIBITORS | PHENOMIX CORPORATION (US) | 2008-03-06 | — | — | WO | disclosed |
| US-7317109-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317109-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2008-01-08 | — | — | US | disclosed |
| US-20070299036-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | PHENOMIX CORPORATION | 2007-12-27 | — | — | US | disclosed |
| US-20060264401-A1 | METHYL AND ETHYL SUBSTITUTED PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | PHENOMIX CORPORATION | 2006-11-23 | — | — | US | disclosed |
| US-20060264400-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | SINO-MED INTERNATIONAL ALLIANCE, INC. | 2006-11-23 | — | — | US | disclosed |
| US-20060264400-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | SINO-MED INTERNATIONAL ALLIANCE, INC. | 2006-11-23 | — | — | US | disclosed |
| US-20060258621-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | SINO-MED INTERNATIONAL ALLIANCE, INC. | 2006-11-16 | — | — | US | disclosed |
| US-20060258621-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | SINO-MED INTERNATIONAL ALLIANCE, INC. | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264400-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | DPP4, DPP7, DPP3 | ATM 4812/4885DPP4 1/4885ALDH1A1 983/4885 |
| US-20060258621-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | DPP4, DPP7, DPP3 | ATM 4789/4885DPP4 1/4885ALDH1A1 1030/4885 |
| US-20120082635-A1 | 2-AMINO-2- [8-(DIMETHYL CARBAMOYL)- 8-AZA- BICYCLO [3.2.1] OCT-3-YL]-EXO- ETHANOYL DERIVATIVES AS POTENT DPP-IV INHIBITORS | DPP7, DPP4, DPP8 | ATM 4805/4885DPP4 2/4885ALDH1A1 1648/4885 |
| US-20060264401-A1 | METHYL AND ETHYL SUBSTITUTED PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | DPP4, DPP3, DPP7 | ATM 4684/4885DPP4 1/4885ALDH1A1 1520/4885 |
| US-20070299036-A1 | PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV | DPP4, DPP7, DPP3 | ATM 4885/4885DPP4 1/4885ALDH1A1 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.