Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963023 | 0.92 | SPHK1 (0.52) | SPHK1SPHK2 | |
| SCHEMBL9299835 | 0.90 | SPHK1 (0.58) | SPHK1SPHK2 | |
| SCHEMBL8962745 | 0.88 | SPHK1 (0.37) | SPHK1SPHK2HDAC2MAOAMAOB | |
| SCHEMBL9478105 | 0.87 | SPHK1 (0.43) | SPHK1SPHK2HDAC2MAOAMAOB | |
| SCHEMBL8963029 | 0.87 | SPHK1 (0.43) | SPHK1SPHK2HDAC2MAOAMAOB | |
| SCHEMBL9478095 | 0.87 | SPHK1 (0.43) | SPHK1SPHK2HDAC2MAOAMAOB | |
| SCHEMBL9478097 | 0.87 | SPHK1 (0.43) | SPHK1SPHK2HDAC2MAOAMAOB | |
| SCHEMBL8835311 | 0.86 | SPHK1 (0.43) | SPHK1SPHK2HDAC2 | |
| SCHEMBL8835308 | 0.86 | SPHK1 (0.43) | SPHK1SPHK2HDAC2 | |
| SCHEMBL9228247 | 0.86 | SPHK1 (0.43) | SPHK1SPHK2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |