SCHEMBL8963248

SCHEMBL8963248

Cc1ccc(C2CCC(/C=C/Cl)CC2)cc1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 1/20 0.41
HDAC2 Q92769 1/20 0.40
ESR2 Q92731 3/20 0.36
MAP1LC3B Q9GZQ8 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
MAPT P10636 1/20 0.36
ATM Q13315 1/20 0.36
ESR1 P03372 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
MAOB P27338 4/20 0.34
MAOA P21397 2/20 0.34
SLC2A1 P11166 1/20 0.33
HTR2C P28335 1/20 0.33
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8963257 1.00 SLC18A3 (0.41) SLC18A3HDAC2ESR2MAP1LC3BSMN1; SMN2
SCHEMBL8962719 0.95 SLC18A3 (0.39) SLC18A3HDAC2ESR2MAP1LC3BSMN1; SMN2
SCHEMBL8962852 0.95 SLC18A3 (0.39) SLC18A3HDAC2ESR2MAP1LC3BSMN1; SMN2
SCHEMBL8962862 0.95 SLC18A3 (0.39) SLC18A3HDAC2ESR2MAP1LC3BSMN1; SMN2
SCHEMBL8963020 0.91 ESR2 (0.41) SLC18A3HDAC2ESR2SMN1; SMN2ALDH1A1
SCHEMBL8963012 0.91 ESR2 (0.41) SLC18A3HDAC2ESR2SMN1; SMN2ALDH1A1
SCHEMBL8963019 0.90 HDAC2 (0.45) SLC18A3HDAC2ESR2ESR1CYP3A4
SCHEMBL8963014 0.90 HDAC2 (0.45) SLC18A3HDAC2ESR2ESR1CYP3A4
SCHEMBL8962818 0.83 HTR3A (0.43) SLC18A3HDAC2MAP1LC3BLMNATP53
SCHEMBL18458816 0.83 SLC18A3 (0.42) SLC18A3HDAC2ESR2MAP1LC3BSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0559860-B1 HALOVINYL-DERIVATIVES HOFFMANN LA ROCHE (CH) 1996-02-14 EP disclosed
US-5364556-A Halovinyl-derivatives HOFFMANN-LA ROCHE INC. (US) 1994-11-15 US disclosed