SCHEMBL8964416

SCHEMBL8964416

COc1ccc2c(c1O)C[C@@H](C(=O)O)NC2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA2 P42262 1/20 0.39
EGLN1 Q9GZT9 1/20 0.39
CHRNB2 P17787 1/20 0.39
CHRNA4 P43681 1/20 0.39
MEN1 O00255 3/20 0.38
ALDH1A1 P00352 3/20 0.38
KMT2A Q03164 3/20 0.38
ALOX12 P18054 1/20 0.38
DRD1 P21728 5/20 0.38
DRD2 P14416 2/20 0.38
F3 P13726 1/20 0.38
KDM4E B2RXH2 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.37
ACHE P22303 1/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP1A2 P05177 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8964041 1.00 GRIA2 (0.39) GRIA2EGLN1CHRNB2CHRNA4MEN1
SCHEMBL26668045 0.85 HTR2A (0.43) GRIA2EGLN1MEN1ALDH1A1KMT2A
SCHEMBL30471814 0.85 HTR2A (0.43) GRIA2EGLN1MEN1ALDH1A1KMT2A
Hydrochloric Acid SCHEMBL25430693 0.84 HTR2A (0.43) GRIA2EGLN1MEN1ALDH1A1KMT2A
SCHEMBL21881432 0.83 KDM4E (0.49) CHRNB2CHRNA4MEN1ALDH1A1KMT2A
SCHEMBL21602706 0.80 MEN1 (0.35) GRIA2EGLN1MEN1ALDH1A1KMT2A
SCHEMBL10072201 0.78 CNR2 (0.43) DRD1
SCHEMBL421422 0.77 AGTR2 (0.56)
SCHEMBL433767 0.77 AGTR2 (0.56)
Hydrochloric Acid SCHEMBL23780714 0.76 AGTR2 (0.55)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5525614-A TREATING VASCULAR RESTENOSIS, CNS DISORDERS WARNER-LAMBERT COMPANY (US) 1996-06-11 US disclosed
US-5489686-A CARDIOVASCULAR DISORDER, NERVOUS SYSTEM DISORDER, ANTIDIURETIC , PSYCHLOGICAL DISORDER, ANTIDEPRESSANTS WARNER-LAMBERT COMPANY (US) 1996-02-06 US disclosed
EP-0641326-A1 SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES WITH ANGIOTENSIN II RECEPTOR ANTAGONIST PROPERTIES WARNER-LAMBERT COMPANY (US) 1995-03-08 EP disclosed
US-5350757-A Treatment of vascular restenosis, nervous system disorders and cognition enhancement WARNER-LAMBERT COMPANY (US) 1994-09-27 US disclosed
WO-1993023378-A1 SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES WITH ANGIOTENSIN II RECEPTOR ANTAGONIST PROPERTIES WARNER-LAMBERT COMPANY (US) 1993-11-25 WO disclosed
US-5246943-A Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties WARNER-LAMBERT COMPANY (US) 1993-09-21 US disclosed