Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 18/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243180 | 0.89 | HTR1A (0.54) | BCHEKDM4EL3MBTL1 | |
| SCHEMBL8032637 | 0.86 | POLB (0.51) | BCHEKDM4EL3MBTL1 | |
| SCHEMBL13888119 | 0.86 | BCHE (0.69) | BCHEKDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL21300617 | 0.85 | BCHE (0.67) | BCHEKDM4EL3MBTL1 | |
| SCHEMBL9802381 | 0.84 | BCHE (0.68) | BCHEKDM4EL3MBTL1 | |
| SCHEMBL6035893 | 0.84 | BCHE (0.68) | BCHEKDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL4107928 | 0.84 | SCN9A (0.54) | BCHEKDM4EL3MBTL1 | |
| SCHEMBL4101732 | 0.84 | ABCB1 (0.56) | BCHEKDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL4098049 | 0.83 | BCHE (0.49) | BCHEKDM4EL3MBTL1 | |
| SCHEMBL3056582 | 0.82 | BCHE (0.64) | BCHEKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478502-B | 1,2,3, 4-tetrahydroisoquinoline derivatives, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-04-27 | — | — | CN | disclosed |
| CN-107922340-B | 1,2,3, 4-tetrahydroisoquinoline derivatives, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-107922340-A | 1,2,3,4 tetrahydro isoquinoline derivatives, its preparation method and application | 上海翰森生物医药科技有限公司 | 2018-04-17 | — | — | CN | disclosed |
| WO-2017036318-A1 | 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2017-03-09 | — | — | WO | disclosed |
| CN-106478502-A | 1,2,3,4- tetrahydro isoquinoline derivative, its preparation method and application | 上海翰森生物医药科技有限公司 | 2017-03-08 | — | — | CN | disclosed |
| US-5525614-A | TREATING VASCULAR RESTENOSIS, CNS DISORDERS | WARNER-LAMBERT COMPANY (US) | 1996-06-11 | — | — | US | disclosed |
| US-5489686-A | CARDIOVASCULAR DISORDER, NERVOUS SYSTEM DISORDER, ANTIDIURETIC , PSYCHLOGICAL DISORDER, ANTIDEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| EP-0641326-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES WITH ANGIOTENSIN II RECEPTOR ANTAGONIST PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-03-08 | — | — | EP | disclosed |
| US-5350757-A | Treatment of vascular restenosis, nervous system disorders and cognition enhancement | WARNER-LAMBERT COMPANY (US) | 1994-09-27 | — | — | US | disclosed |
| WO-1993023378-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES WITH ANGIOTENSIN II RECEPTOR ANTAGONIST PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5246943-A | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties | WARNER-LAMBERT COMPANY (US) | 1993-09-21 | — | — | US | disclosed |